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Clin Rheumatol. 2009 Mar;28(3):347-50. doi: 10.1007/s10067-008-1062-2. Epub 2008 Dec 6.

Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: follow-up of immunopathological and clinical effects.

Author information

1
Department of Rheumatology, University of Debrecen Medical Center, 22 Moricz street, Debrecen 4004, Hungary. szekanecz@iiibel.dote.hu

Abstract

Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.

PMID:
19067103
DOI:
10.1007/s10067-008-1062-2
[Indexed for MEDLINE]

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