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Br J Cancer. 2009 Jan 13;100(1):113-7. doi: 10.1038/sj.bjc.6604812. Epub 2008 Dec 9.

Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40.

Author information

1
Department of Preclinical Therapeutics, Seattle Genetics Inc., Seattle, WA 98021, USA.

Abstract

SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions.

PMID:
19066610
PMCID:
PMC2634668
DOI:
10.1038/sj.bjc.6604812
[Indexed for MEDLINE]
Free PMC Article

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