Format

Send to

Choose Destination
Stroke. 2009 Mar;40(3 Suppl):S13-5. doi: 10.1161/STROKEAHA.108.533117. Epub 2008 Dec 8.

Pericyte signaling in the neurovascular unit.

Author information

1
Department of Neurology, UC Irvine Medical Center, 101 The City Drive South, Shanbrom Hall, Room 121, Orange, CA 92868, USA. mfisher@uci.edu

Abstract

Brain pericytes are intimately associated with capillary endothelial cells, separated only by basement membrane. Pericyte research has been hampered by absence of pericyte-specific immunochemical markers. The vast array of pericyte functions include contractility, immunologic, migratory, and angiogenic. Pericytes have stem cell potential, contribute to the integrity of the blood-brain barrier, and have a regulatory role for hemostasis in the brain. Improvement in pericyte identification is likely to lead to marked increase in appreciation of the role of pericytes in the neurovascular unit.

PMID:
19064799
PMCID:
PMC2724312
DOI:
10.1161/STROKEAHA.108.533117
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center