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Stroke. 2009 Mar;40(3 Suppl):S61-3. doi: 10.1161/STROKEAHA.108.533182. Epub 2008 Dec 8.

Whole genome approaches in ischemic stroke.

Author information

1
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. meschia.james@mayo.edu

Abstract

BACKGROUND AND PURPOSE:

The field of ischemic stroke genetics is moving beyond candidate gene studies into the realm of genomewide association studies. Such studies have resulted in discoveries in diverse, complex disorders.

METHODS:

The author conducted an informal qualitative review of peer-reviewed medical literature.

RESULTS:

The power of genomewide association studies to confirm prior associations and establish new ones is illustrated by recent work focusing on type 2 diabetes mellitus. A pilot genomewide association study of ischemic stroke failed to identify a single gene of major effect.

CONCLUSIONS:

Follow-up studies with substantially greater statistical power are essential and are being planned by the Wellcome Trust and others.

PMID:
19064793
PMCID:
PMC3932690
DOI:
10.1161/STROKEAHA.108.533182
[Indexed for MEDLINE]
Free PMC Article

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