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Stroke. 2009 Mar;40(3 Suppl):S88-9. doi: 10.1161/STROKEAHA.108.533281. Epub 2008 Dec 8.

Thrombin and brain recovery after intracerebral hemorrhage.

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1
R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.

Abstract

Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema, and neuronal death after ICH, our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis, and plasticity may facilitate brain recovery after ICH.

PMID:
19064789
PMCID:
PMC2649979
DOI:
10.1161/STROKEAHA.108.533281
[Indexed for MEDLINE]
Free PMC Article
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