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Arch Neurol. 2008 Dec;65(12):1577-81. doi: 10.1001/archneur.65.12.1577.

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease.

Author information

1
Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Bldg 114, 3300 16th St, Charlestown, MA 02129-4404, USA. akazantsev@partners.org

Abstract

Selective death of nigrostriatal neurons, which leads to Parkinson disease, is explained by misfolding of brain protein alpha-synuclein. Herein, we review the data supporting this concept, propose a scheme of events leading to synuclein-induced neuronal death, and discuss protein deacetylase sirtuins as new potential therapeutic targets involved in this process.

PMID:
19064744
DOI:
10.1001/archneur.65.12.1577
[Indexed for MEDLINE]

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