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Expert Opin Ther Targets. 2009 Jan;13(1):29-38. doi: 10.1517/14728220802564390 .

Vitamin D and the vasculature: can we teach an old drug new tricks?

Author information

1
Hospital Universitario Arnau de Vilanova, Experimental Nephrology Laboratory, Spain. Valdivielso@medicina.udl.es

Abstract

BACKGROUND:

Vitamin D is a steroid hormone known for its role in regulating levels of calcium and phosphorus. Vitamin D has important autocrine/paracrine roles and it is involved in vascular biology. Clinical studies have shown a relationship between vitamin D levels and cardiovascular health, and low levels of vitamin D metabolites have been associated with higher incidence of congestive heart failure and increases in mortality.

OBJECTIVE:

To summarise the effect of vitamin D on cardiovascular pathology, the leading cause of death in chronic kidney disease patients.

CONCLUSIONS:

All results indicate a potential effect of vitamin D on cardiovascular health. Therefore, maintaining optimum levels of circulating vitamin D is critical for a healthy cardiovascular system. In patients with low vitamin D status, like renal patients, supplementation with vitamin D metabolites has shown beneficial cardiovascular effects.

PMID:
19063704
DOI:
10.1517/14728220802564390
[Indexed for MEDLINE]

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