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Expert Opin Biol Ther. 2009 Jan;9(1):21-8. doi: 10.1517/14712590802603093 .

A novel role for the marrow microenvironment in initiating and sustaining hematopoietic disease.

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1
University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

Abstract

BACKGROUND:

The marrow microenvironment is composed of a complex network of cells and extra cellular matrix that cooperate to regulate normal hematopoiesis. There is growing evidence that microenvironmental defects can contribute to the pathogenesis of hematological malignancies.

OBJECTIVE/METHODS:

We review the role of the microenvironment in inducing and sustaining hematological malignancies.

RESULTS/CONCLUSIONS:

Two basic mechanisms could explain the role of microenvironmental defects in the evolution of hematopoietic neoplasms. There is significant data to support the first mechanism, in which the malignant hematopoietic clone induces reversible functional changes in the microenvironment that result in improved growth conditions for the malignant cells. More recent studies from mouse models have indicated that a second mechanism involving primary microenvironmental defects can also result in malignancy.

PMID:
19063690
PMCID:
PMC2911479
DOI:
10.1517/14712590802603093
[Indexed for MEDLINE]
Free PMC Article
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