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Trends Cell Biol. 2009 Jan;19(1):24-8. doi: 10.1016/j.tcb.2008.11.001. Epub 2008 Dec 4.

CGH-1 and the control of maternal mRNAs.

Author information

1
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0106, USA.

Abstract

Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to P-bodies and stress granules, which are conserved RNP granules seen in somatic cells. In addition, a highly conserved putative RNA helicase, termed CGH-1 in C. elegans, is now shown to be important for both for translation repression and the stability of stored mRNAs. The analysis of CGH-1 ortholog functions in somatic cells and its interacting proteins indicate possible mechanisms by which this protein family might stabilize stored maternal mRNAs.

PMID:
19062290
DOI:
10.1016/j.tcb.2008.11.001
[Indexed for MEDLINE]

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