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Fertil Steril. 2010 Feb;93(3):885-93. doi: 10.1016/j.fertnstert.2008.10.012. Epub 2008 Dec 4.

Body composition, smoking, and spontaneous dizygotic twinning.

Author information

1
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.

Abstract

OBJECTIVE:

To examine differences in body composition and smoking between mothers of spontaneous monozygotic and dizygotic twins, while taking into account maternal age, gravidity, and educational attainment.

DESIGN:

Retrospective cohort study.

SETTING:

The Netherlands Twin Register.

PATIENT(S):

Mothers of twins (n = 19,357) registered with the Netherlands Twin Register. Data were selected from mothers of spontaneous monozygotic twins (MZ; n = 5663) and mothers of spontaneous dizygotic twins (DZ; n = 8515).

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The odds of having spontaneous DZ twins versus spontaneous MZ twins as a function of height, body mass index (BMI), and smoking before pregnancy, after accounting for age, gravidity, and educational attainment.

RESULT(S):

Compared with spontaneous MZ twinning, spontaneous DZ twinning is significantly associated with increasing height (odds ratio, 1.6; 95% confidence interval [CI], 1.5-1.8 for the tallest versus the shortest height quartile), an increased BMI (odds ratio, 1.3; 95% CI, 1.1-1.4 for overweight vs. normal weight), and smoking before the twin pregnancy (odds ratio, 1.4; 95% CI, 1.3-1.5 for smoker vs. nonsmoker). Maternal age and gravidity, but not educational attainment, had to be included in the model.

CONCLUSION(S):

Spontaneous dizygotic twinning is associated with body composition and smoking.

[Indexed for MEDLINE]

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