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Cancer Cell. 2008 Dec 9;14(6):431-3. doi: 10.1016/j.ccr.2008.11.011.

The aneuploidy paradox in cell growth and tumorigenesis.

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1
Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53706, USA. baweaver@wisc.edu

Abstract

Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.

PMID:
19061834
PMCID:
PMC3132552
DOI:
10.1016/j.ccr.2008.11.011
[Indexed for MEDLINE]
Free PMC Article
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