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Mol Cell. 2008 Dec 5;32(5):605-15. doi: 10.1016/j.molcel.2008.11.001.

The control of mRNA decapping and P-body formation.

Author information

1
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Abstract

mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is stimulated by decapping enhancer proteins. mRNAs associated with the decapping machinery can assemble into cytoplasmic mRNP granules called processing bodies (PBs). Evidence suggests that PB-associated mRNPs are translationally repressed and can be degraded or stored for subsequent translation. However, whether mRNP assembly into a PB is important for translational repression, decapping, or decay has remained controversial. Here, we discuss the regulation of decapping machinery recruitment to specific mRNPs and how their assembly into PBs is governed by the relative rates of translational repression, mRNP multimerization, and mRNA decay.

PMID:
19061636
PMCID:
PMC2630519
DOI:
10.1016/j.molcel.2008.11.001
[Indexed for MEDLINE]
Free PMC Article

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