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Dermatol Online J. 2008 Sep 15;14(9):2.

Acanthosis nigricans: a practical approach to evaluation and management.

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Division of Dermatology, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA.


Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management.

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