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Org Lett. 2009 Jan 1;11(1):57-60. doi: 10.1021/ol802339w.

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Author information

1
Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, NCIFrederick, Frederick, Maryland 21702, USA.

Abstract

An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited the growth of renal cancer cell lines. Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A (1) and B (2). Englerin A showed 1000-fold selectivity against six of eight renal cancer cell lines with GI(50) values ranging from 1-87 nM. The structures of 1 and 2 and their relative stereochemistry were established by spectroscopic methods.

PMID:
19061394
PMCID:
PMC2651161
DOI:
10.1021/ol802339w
[Indexed for MEDLINE]
Free PMC Article

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