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Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1814-8. doi: 10.1167/iovs.08-2656. Epub 2008 Dec 5.

Coenzyme Q10 in the human retina.

Author information

1
Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, USA.

Abstract

PURPOSE:

To determine the concentration of coenzyme Q10 (CoQ10) in the human retina.

METHODS:

Eye tissues were lyophilized and exhaustively extracted with heptane. The extracts were analyzed for CoQ10 by high-performance liquid chromatography (HPLC).

RESULTS:

The average concentration of CoQ10 in the retina was 42+/-11 nanomoles/g dry retina for donors younger than 30 years of age and 24+/-13 nanomoles/g dry retina for donors older than 80 years of age. The average concentrations of CoQ10 in the choroid was 27+/-16 nanomoles/g dry choroid for donors younger than 30 age and 18+/-11 nanomoles/g dry choroid for donors older than 80.

CONCLUSIONS:

CoQ10 levels in the retina can decline by approximately 40% with age. This decline may have two consequences: a decrease in antioxidant ability and a decrease in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progression of macular degeneration.

PMID:
19060288
DOI:
10.1167/iovs.08-2656
[Indexed for MEDLINE]

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