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Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19998-20003. doi: 10.1073/pnas.0808312105. Epub 2008 Dec 5.

Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation.

Author information

1
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Light detected in the retina modulates several physiological processes including circadian photo-entrainment and pupillary light reflex. Intrinsically photosensitive retinal ganglion cells (ipRGCs) convey rod-cone and melanopsin-driven light input to the brain. Using EEGs and electromyograms, we show that acute light induces sleep in mice during their nocturnal active phase whereas acute dark awakens mice during their diurnal sleep phase. We used retinal mutant mouse lines that lack (i) the ipRGCs, (ii) the photo-transduction pathways of rods and cones, or (iii) the melanopsin protein and showed that the influence of light and dark on sleep requires both rod-cone and melanopsin signaling through ipRGCs and is independent of image formation. We further show that, although acute light pulses overcome circadian and homeostatic drives for sleep, upon repeated light exposures using a 3.5 h/3.5 h light/dark cycle, the circadian and homeostatic drives override the light input. Thus, in addition to their known role in aligning circadian physiology with day and night, ipRGCs also relay light and dark information from both rod-cone and melanopsin-based pathways to modulate sleep and wakefulness.

PMID:
19060203
PMCID:
PMC2596746
DOI:
10.1073/pnas.0808312105
[Indexed for MEDLINE]
Free PMC Article

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