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Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. doi: 10.1016/j.bmcl.2008.11.062. Epub 2008 Nov 21.

Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.

Author information

1
UCB Celltech, 216 Bath Road, Slough SL1 3WE, United Kingdom. john.porter@ucb-group.com

Abstract

A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the series are discussed together with the identification of a novel quinoline scaffold.

PMID:
19059779
DOI:
10.1016/j.bmcl.2008.11.062
[Indexed for MEDLINE]

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