Send to

Choose Destination
J Mol Biol. 2009 Jan 23;385(3):726-32. doi: 10.1016/j.jmb.2008.11.028. Epub 2008 Nov 25.

A periodic table of coiled-coil protein structures.

Author information

School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.


Coiled coils are protein structure domains with two or more alpha-helices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a "periodic table of coiled coils," which we have made available at In this table, coiled-coil assemblies are arranged in columns with increasing numbers of alpha-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center