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FEBS Lett. 2009 Jan 5;583(1):1-6. doi: 10.1016/j.febslet.2008.11.032. Epub 2008 Dec 4.

Breaking the VE-cadherin bonds.

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1
Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris, France. julie.gavard@inserm.fr

Abstract

Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis.

PMID:
19059243
DOI:
10.1016/j.febslet.2008.11.032
[Indexed for MEDLINE]
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