Format

Send to

Choose Destination
See comment in PubMed Commons below
J Dermatol Sci. 2009 Mar;53(3):169-75. doi: 10.1016/j.jdermsci.2008.10.004. Epub 2008 Dec 5.

MicroRNAs and the skin: tiny players in the body's largest organ.

Author information

1
Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, 44791 Bochum, Germany. michael.sand@ruhr-uni-bochum.de

Abstract

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. Disruption of miRNA metabolism is also involved in wound healing and inflammatory skin conditions. Here, we review the role of miRNAs in cutaneous biology.

PMID:
19058951
DOI:
10.1016/j.jdermsci.2008.10.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center