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Thromb Res. 1991 Feb 15;61(4):433-40.

Fibrinogen does not protect von Willebrand factor against proteolysis by human cathepsin G.

Author information

1
Institute of Hematology, Warsaw, Poland.

Abstract

The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinogen added in excess to purified FVIII/vWF concentrate does not protect vWF against cathepsin G proteolysis. Biological significance of this phenomena are discussed.

PMID:
1905850
DOI:
10.1016/0049-3848(91)90657-i
[Indexed for MEDLINE]

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