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Crit Rev Biochem Mol Biol. 2008 Nov-Dec;43(6):419-33. doi: 10.1080/10409230802605914 .

Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex.

Author information

1
Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA. sbhaumik@siumed.edu

Abstract

The life of any protein within a cell begins with transcriptional activation, and ends with proteolytic degradation. Intriguingly, the 26S proteasome complex, a non-lysosomal protein degradation machine comprising the 20S proteolytic core and 19S regulatory particles, has been implicated in intimate regulation of eukaryotic transcriptional activation through diverse mechanisms in a proteolysis-dependent as well as independent manner. Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways.

PMID:
19058045
DOI:
10.1080/10409230802605914
[Indexed for MEDLINE]

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