Format

Send to

Choose Destination
J Perinatol. 2008 Dec;28 Suppl 3:S67-71. doi: 10.1038/jp.2008.158.

Nitric oxide and beyond: new insights and therapies for pulmonary hypertension.

Author information

1
Department of Pediatrics, Division of Neonatology, Children's Memorial Hospital, Northwestern University's Feinberg School of Medicine, Chicago, IL 60614, USA. r-steinhorn@northwestern.edu

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) contributes significantly to the morbidity and mortality associated with meconium aspiration syndrome. This review article discusses new insights into the vascular abnormalities that are associated with PPHN, including the recent recognition of the importance of oxidant stress in its pathogenesis. Recent data are presented showing that treatment with high oxygen concentrations may increase production of oxygen free radicals. The rationale for the use of inhaled nitric oxide, and strategies for enhancing nitric oxide signaling are discussed. Finally, the rationale for new treatment approaches is reviewed, including inhibition of cyclic guanosine monophosphate-specific phosphodiesterases and scavengers of reactive oxygen species.

PMID:
19057613
PMCID:
PMC2739741
DOI:
10.1038/jp.2008.158
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center