Format

Send to

Choose Destination
Curr Opin Hematol. 2009 Jan;16(1):27-34. doi: 10.1097/MOH.0b013e32831c8407.

Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia.

Author information

1
Experimental Hematology and Hematopoiesis Section, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Abstract

PURPOSE OF REVIEW:

T-cell large granular lymphocyte leukemia is a chronic clonal lymphoproliferation of cytotoxic T cells often associated with immune-mediated cytopenias. The pathophysiology of cytopenias includes cytokine effects and direct antigen-specific cytotoxicity to hematopoietic precursors. This review will address the diagnostic challenges of and therapeutic options for T-cell large granular lymphocyte leukemia.

RECENT FINDINGS:

Immunosuppressive therapy, with cyclosporine, methotrexate, and oral cyclophosphamide, is often used, but formal trials have not been performed and response rates are poorly established. In refractory cases, alternative regimens such as antithymocyte globulin or monoclonal antibody therapy have exhibited hematologic response.

SUMMARY:

T-cell large granular lymphocyte leukemia may assume an indolent course but sometimes manifests with significant cytopenias. A majority of patients will ultimately require immunosuppressive therapy due to symptomatic neutropenia or anemia. In these cases, a variety of agents maybe used successfully though chronic therapy is often necessary.

PMID:
19057202
DOI:
10.1097/MOH.0b013e32831c8407
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center