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Genes Dev. 2008 Nov 15;22(22):3077-81. doi: 10.1101/gad.1741008.

Wnt-induced proteolytic targeting.

Author information

1
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. jones@salk.edu

Abstract

Misregulation of the Wnt pathway is a common route to cancer, including primary breast cancers. In this issue of Genes & Development, Miranda-Carboni and colleagues (3121-3134) demonstrate that the cyclin-dependent kinase inhibitor p27(Kip1) is ubiquitylated for proteasomal degradation in Wnt10b-induced mammary tumors exclusively by the Cul4A E3 ligase, which is strongly induced by Wnt signaling. The discovery of a new Wnt-induced proteolytic targeting system has important implications for the mechanism of Wnt-initiated tumorigenesis.

PMID:
19056888
PMCID:
PMC2751624
DOI:
10.1101/gad.1741008
[Indexed for MEDLINE]
Free PMC Article
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