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Parkinsonism Relat Disord. 2009 Mar;15(3):245-8. doi: 10.1016/j.parkreldis.2008.05.012. Epub 2008 Dec 4.

Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington's disease.

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Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.



Neurofilaments are major structural elements of neuronal cells. The light subunit of neurofilament triplet protein (NFL) has been shown to be increased in several neurological diseases (e.g. vascular, infectious, neurodegenerative), indicating axonal damage.


In this study we analyzed the NFL levels in all (N=35) available cerebrospinal fluid (CSF) samples from a clinical trial in Huntington's disease (HD) and compared them to age and gender matched controls.


The CSF-NFL levels were significantly higher in HD subjects compared with age and genders matched controls, and were correlated with scores on the Unified Huntington's Disease Rating Scale Total Functional Capacity assessment. The potential of CSF-NFL levels as a disease activity marker in HD needs to be further investigated.

[Indexed for MEDLINE]

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