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Int J Immunogenet. 2009 Feb;36(1):69-72. doi: 10.1111/j.1744-313X.2008.00816.x. Epub 2008 Nov 25.

MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders.

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Department of Pathophysiology, Medical Faculty, Masaryk University, Brno, Czech Republic.


Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n = 306) and allergic patients (n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.

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