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Protein Eng Des Sel. 2009 Mar;22(3):189-98. doi: 10.1093/protein/gzn070. Epub 2008 Dec 2.

A humanized anti-M2 scFv shows protective in vitro activity against influenza.

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Department of Infectious Diseases, Animal Health Research Center, Influenza Pathogenesis and Immunology Research Center, University of Georgia, Athens, 30602-1563, USA.


M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar activity to the parental mAb: it is able to recognize M2 in its native context on cell surfaces and is able to show protective in vitro activity against influenza, and so represents a potential lead antibody candidate for universal prophylactic or therapeutic intervention in influenza.

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