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J Biol Chem. 2009 Apr 3;284(14):9017-21. doi: 10.1074/jbc.R800075200. Epub 2008 Dec 2.

Cyclic nucleotide-regulated cation channels.

Author information

1
Center for Integrated Protein Science Munich and Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany. mbiel@cup.uni-muenchen.de

Abstract

Cyclic nucleotide-regulated cation channels are ion channels whose activation is regulated by the direct binding of cAMP or cGMP to the channel protein. Two structurally related families of channels regulated by cyclic nucleotides have been identified, the cyclic nucleotide-gated channels and the hyperpolarization-activated cyclic nucleotide-gated channels. Cyclic nucleotide-gated channels play a key role in visual and olfactory transduction. Hyperpolarization-activated cyclic nucleotide-gated channels are present in the conduction system of the heart and are involved in the control of cardiac automaticity. Moreover, these channels are widely expressed in central and peripheral neurons, where they control a variety of fundamental processes.

PMID:
19054768
PMCID:
PMC2666549
DOI:
10.1074/jbc.R800075200
[Indexed for MEDLINE]
Free PMC Article

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