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Org Lett. 2008 Dec 18;10(24):5529-31. doi: 10.1021/ol802286g.

In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.

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1
Department of Chemistry, NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543.

Abstract

A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.

PMID:
19053720
DOI:
10.1021/ol802286g
[Indexed for MEDLINE]
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