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J Am Chem Soc. 2008 Dec 24;130(51):17248-9. doi: 10.1021/ja8076236.

Alpha-helix stabilization within a peptide dendrimer.

Author information

1
Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland.

Abstract

The alpha-helical second generation peptide dendrimer of sequence (AcAMEA)(4)(KKLME)(2)KMKLA is more stable than the corresponding linear peptide AcAMEAAKLMEAMKLA toward pH-induced unfolding and temperature-induced intermolecular aggregation. The effect is interpreted in terms of an alpha-helix spanning across two successive branching points of the dendrimer. This stabilization effect is unprecedented and opens the way to folded dendritic analogues of proteins using natural amino acids only.

PMID:
19053200
DOI:
10.1021/ja8076236
[Indexed for MEDLINE]

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