Format

Send to

Choose Destination
Intern Emerg Med. 2009 Feb;4(1):25-34. doi: 10.1007/s11739-008-0207-2. Epub 2008 Dec 4.

Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?

Author information

1
Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy. paolo.calabro@unina2.it

Abstract

Until relatively recently, the role of adipose tissue in the development of obesity and its consequences was considered to be a passive one. Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. It is now clear that, in addition to storing calories as triglycerides, adipocytes secrete a large variety of cytokines, chemokines and hormone-like factors, such as leptin, resistin, and acute-phase proteins. In addition, insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly with an excess of intraabdominal fat. This production of pro-atherogenic substances is of particular interest since an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.

PMID:
19052701
DOI:
10.1007/s11739-008-0207-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center