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Bioinformation. 2008;3(1):53-7. Epub 2008 Oct 7.

Molecular epigenetics, chromatin, and NeuroAIDS/HIV: translational implications.

Author information

1
Division of Infectious Diseases and International Medicine, Departments of Internal Medicine and of Psychiatry and Behavioral Medicine, University of South Florida Health, Tampa, FL 33606, USA. pshapshak@gmail.com

Abstract

We describe current research that applies epigenetics to a novel understanding of the immuno-neuropathogenesis of HIV-1 viral infection and NeuroAIDS. We propose the hypothesis that HIV-1 alters the structure-function relationship of chromatin, coding DNA and non-coding DNA, including RNA transcribed from these regions resulting in pathogenesis in AIDS, drug abuse, and NeuroAIDS. We discuss the general implications of molecular epigenetics with special emphasis on drug abuse, bar-codes, pyknons, and miRNAs for translational and clinical research. We discuss the application of the recent recursive algorithm of biology to this field and propose to synthesize the Genomic and Epigenomic views into a holistic approach of HoloGenomics.

KEYWORDS:

AIDS; HIV-1; NeuroAIDS; coding and noncoding DNA; epigenetics; hologenomics; molecular medicine paradigm-shift; translation-clinic

PMID:
19052667
PMCID:
PMC2586134

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