Format

Send to

Choose Destination
Am J Trop Med Hyg. 2008 Dec;79(6):823-5.

Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria.

Author information

1
Institute of Medical Science, McLaughlin-Rotman Centre for Global Health, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract

Cerebral malaria is responsible for a high proportion of mortality in human Plasmodium falciparum infection. Previous studies have reported the presence of apoptosis in endothelial cells, astrocytes, neurons, and glial cells in experimental murine cerebral malaria caused by infection with Plasmodium berghei ANKA. Using this model, we tested two strategies, which have been shown to improve survival in murine models of sepsis: 1) treatment with z-VAD, a pancaspase inhibitor; and 2) overexpression of Bcl-2 using transgenic mice expressing human Bcl-2 (which prevents the release of apoptotic mediators from the mitochondria) from a myeloid cell promoter. Neither of these anti-apoptotic strategies, previously shown to provide therapeutic benefit in sepsis, improved survival in experimental cerebral malaria.

PMID:
19052286
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ingenta plc
Loading ...
Support Center