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Drug Discov Today. 2009 Jan;14(1-2):102-7. doi: 10.1016/j.drudis.2008.11.006. Epub 2008 Dec 26.

3D cell culture opens new dimensions in cell-based assays.

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Global Cell Solutions, Inc., 770 Harris Street, Suite 104, Charlottesville, VA 22903, USA.


3D cell culture technologies have revolutionized our understanding of cellular behavior, both in culture and in vivo, but adoption by cell-based screening groups has been slow owing to problems of consistency, scale and cost. The evolving field of high content screening technologies will, however, require a rethinking of 3D cell culture adoption to ensure the next generation of cells provide relevant in vivo-like data. Three current technologies are presented in this review: membranes, sponges/gels and microcarriers. A short history of these technologies and unique research applications are discussed. Also, the technologies are evaluated for usefulness in modern automated cell-based screening equipment.

[Indexed for MEDLINE]

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