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Epilepsia. 2008 Nov;49 Suppl 8:111-3. doi: 10.1111/j.1528-1167.2008.01852.x.

Diet, ketones, and neurotrauma.

Author information

1
Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095-7039, USA. mprins@mednet.ucla.edu

Abstract

The annual incidence of traumatic brain injury far exceeds the rates of any other disease in the United States, yet progress toward age-relevant therapies, attention to patients needs, and research funding have all been minimal. Cerebral metabolism of glucose has been shown to be altered after head injury, and increasing cerebral metabolism of alternative substrates (ketones) has been shown to be neuroprotective in several models of traumatic brain injury. This altered dietary approach may have tremendous therapeutic potential for both the pediatric and adult head-injured populations.

PMID:
19049605
PMCID:
PMC2652873
DOI:
10.1111/j.1528-1167.2008.01852.x
[Indexed for MEDLINE]
Free PMC Article

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