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Epilepsia. 2008 Nov;49 Suppl 8:108-10. doi: 10.1111/j.1528-1167.2008.01851.x.

A new rat model for vulnerability to epilepsy and autism spectrum disorders.

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1
Institute of Neuroscience, Life Sciences Research Center, Carleton University, Ottawa, Ontario, Canada. krista gilby@carleton.ca

Abstract

Tremendous concern has arisen in response to the recent diagnostic outbreak of childhood developmental disorders, particularly involving attention deficit hyperactivity disorder (ADHD) and the autism spectrum disorders (ASD). Interestingly, similarities in clinical presentation across these disorders may suggest common predisposing factors. For instance, though not widely recognized, an increased predisposition toward seizure is a symptom that is very often associated with ADHD and ASD. Accordingly, a rat strain naturally bred to be seizure-prone simultaneously developed behavioral and physical characteristics analogous to those observed in ADHD/ASD patients. These rats also show early signs of aberrant lipid handling, which is another symptom common to human patients with these disorders. As such, this rat strain could serve as an excellent model system through which to identify common pathophysiological events that constitute a"spectrum of vulnerability"toward ADHD/ASD and epilepsy.

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