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Epilepsia. 2008 Nov;49 Suppl 8:73-5. doi: 10.1111/j.1528-1167.2008.01841.x.

Ketosis and brain handling of glutamate, glutamine, and GABA.

Author information

1
Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. yudkoff@email.chop.edu

Abstract

We hypothesize that one mechanism of the anti-epileptic effect of the ketogenic diet is to alter brain handling of glutamate. According to this formulation, in ketotic brain astrocyte metabolism is more active, resulting in enhanced conversion of glutamate to glutamine. This allows for: (a) more efficient removal of glutamate, the most important excitatory neurotransmitter; and (b) more efficient conversion of glutamine to GABA, the major inhibitory neurotransmitter.

PMID:
19049594
PMCID:
PMC2722878
DOI:
10.1111/j.1528-1167.2008.01841.x
[Indexed for MEDLINE]
Free PMC Article

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