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Microbiology. 2008 Dec;154(Pt 12):3609-23. doi: 10.1099/mic.0.2008/022772-0.

Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins.

Author information

1
Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK. sarah.maddocks@bristol.ac.uk

Abstract

The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix-turn-helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.

PMID:
19047729
DOI:
10.1099/mic.0.2008/022772-0
[Indexed for MEDLINE]

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