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Pediatr Rheumatol Online J. 2008 Dec 1;6:20. doi: 10.1186/1546-0096-6-20.

Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development.

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Department of Pediatrics, UCSF, San Francisco, CA 94143, USA.


Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.

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