Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Cell Biol. 2008 Dec;10(12):1379-82. doi: 10.1038/ncb1208-1379.

Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?

Author information

1
Department of Zoology, Downing Street, University of Cambridge, Cambridge CB2 3EJ, UK. pal@mrc-lmb.cam.ac.uk

Abstract

Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell movement and possibly in the orientation of axon extension. Another popular area in current research is growth: there is an attempt to find systems that fix the shape and size of organs. Although both polarity and growth are subject to overall control by morphogen gradients, the mechanisms of this control are almost completely unknown. Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development.

PMID:
19043429
PMCID:
PMC2747020
DOI:
10.1038/ncb1208-1379
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center