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Cell Stem Cell. 2008 Dec 4;3(6):575-6. doi: 10.1016/j.stem.2008.11.004.

ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

Author information

1
Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska Institute, Nobelsv 3, 171 77 Stockholm, Sweden. eva.hedlund@licr.ki.se

Abstract

In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.

PMID:
19041769
DOI:
10.1016/j.stem.2008.11.004
[Indexed for MEDLINE]
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