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Cell. 2008 Nov 28;135(5):797-8. doi: 10.1016/j.cell.2008.11.008.

Aging: a sirtuin shake-up?

Author information

1
Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. jvijg@aecom.yu.edu

Abstract

The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.

PMID:
19041745
DOI:
10.1016/j.cell.2008.11.008
[Indexed for MEDLINE]
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