Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 2009 Feb 3;1252:45-51. doi: 10.1016/j.brainres.2008.10.079. Epub 2008 Nov 13.

Activity-dependent regulation of myelin maintenance in the adult rat.

Author information

  • 1Laboratoire de Plasticit√© Neuromusculaire, EA 4345, IFR 147, Universit√© des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq cedex, France.


Hindlimb unloading (HU) is known to induce changes in the neuromuscular system. However, no data describing the effects of HU on morphological characteristics of peripheral nerve have been reported so far. Therefore, we used soleus and radial nerves obtained from control and rats submitted to 14 days of HU to study the consequences of a decrease (soleus) or an increase (radial) in neural activity on its morphology. The mean number of fibers was not changed after HU. The soleus nerve axon diameter was weakly affected after HU, whereas the myelin thickness was reduced. For the radial nerve, both axon and fiber diameter were increased, and the myelin thickness and internodal distance were higher in HU rats. These results suggest that regulation of myelin maintenance undergoes plastic mechanisms. Neural activity and/or neural pattern might be essential in the maintenance of myelin sheath in adults.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center