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Int J Eat Disord. 2009 May;42(4):293-300. doi: 10.1002/eat.20610.

The hematology of anorexia nervosa.

Author information

1
Department of Internal Medicine III Hematology, Oncology, and Transfusion Medicine, Charité Campus Benjamin Franklin, Berlin, Germany. gero.huetter@charite.de

Abstract

OBJECTIVE:

Changes of the peripheral blood cell count in patients with anorexia nervosa (AN) are frequent. Anemia and leukopenia are observed in one-third of these patients. Examination of the bone marrow reveals in almost 50% of the patients with AN signs of bone marrow atrophy and can additionally suffer from a gelatinous bone marrow transformation.

METHOD:

Published studies and investigations concerning hematological changes in patients with AN were reviewed.

RESULTS:

Anemia and mild neutropenia are detectable in almost one-third of these patients, whereas thrombocytopenia is rather uncommon. The exact mechanism for these findings is still unclear, but 50% of AN-patients with hematological changes display morphological signs of partial bone marrow atrophy.

DISCUSSION:

Changes of the peripheral blood cell count in patients with AN is a frequent observation but the peripheral blood cell count cannot predict the severity of bone marrow atrophy. All hematological and morphological alterations disappear completely and rapidly after sufficient refeeding.

PMID:
19040272
DOI:
10.1002/eat.20610
[Indexed for MEDLINE]

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