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Planta Med. 2009 Jan;75(1):70-5. doi: 10.1055/s-0028-1088369. Epub 2008 Nov 27.

Triterpenoid saponins from Ardisia pusilla and their cytotoxic activity.

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Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.


Three new triterpenoid saponins 3, 4 and 5, together with two known saponins, ardisiacrispin B (1) and ardisiacrispin A (2), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidence. Compound 3 is a hexaglycoside with a 13,28-epoxyoleanane type aglycone, while both 4 and 5 are triterpenoid tetraglycosides related to the olean-12-ene skeleton. Saponins 1-4 exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.

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