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Org Biomol Chem. 2008 Dec 21;6(24):4494-7. doi: 10.1039/b815963g. Epub 2008 Oct 17.

Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates.

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1
Alpha-Chimica, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, France.

Abstract

A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which can also be used for the preparation of new products.

PMID:
19039354
DOI:
10.1039/b815963g
[Indexed for MEDLINE]
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