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Am J Geriatr Psychiatry. 2008 Dec;16(12):999-1009. doi: 10.1097/JGP.0b013e31818cd3a4.

Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study.

Author information

1
Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA. gsmall@mednet.ucla.edu

Abstract

OBJECTIVE:

Because anti-inflammatory drugs may delay cognitive decline and influence brain metabolism in normal aging, the authors determined the effects of the cyclooxygenase-2 inhibitor, celecoxib, on cognitive performance and regional cerebral glucose metabolism in nondemented volunteers with mild age-related memory decline.

DESIGN:

Randomized, double-blind, placebo-controlled, parallel group trial with 18-months of exposure to study medication.

SETTING:

University research institute.

PARTICIPANTS:

Eighty-eight subjects, aged 40-81 years (mean: 58.7, SD: 8.9 years) with mild self-reported memory complaints but normal memory performance scores were recruited from community physician referrals, media coverage, and advertising. Forty subjects completed the study.

INTERVENTIONS:

Daily celecoxib dose of 200 or 400 mg, or placebo.

MAIN OUTCOME MEASURES:

Standardized neuropsychological test battery and statistical parametric mapping (SPM) of FDG-PET scans performed during mental rest.

RESULTS:

Measures of cognition showed significant between-group differences in executive functioning (F [1, 30] = 5.06, p = 0.03) and language/semantic memory (F [1, 31] = 6.19, p = 0.02), favoring the celecoxib group compared with the placebo group. Concomitantly, FDG-PET scans demonstrated bilateral metabolic increases in prefrontal cortex in the celecoxib group in the vicinity of Brodmann's areas 9 and 10, but not in the placebo group. SPM analyses of the PET data pooled by treatment arm corresponded to a 6% increase in activity over pretreatment levels (p <0.01, after adjustment for multiple comparisons).

CONCLUSIONS:

These results suggest that daily celecoxib use may improve cognitive performance and increase regional brain metabolism in people with age-associated memory decline.

PMID:
19038899
PMCID:
PMC2693408
DOI:
10.1097/JGP.0b013e31818cd3a4
[Indexed for MEDLINE]
Free PMC Article

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