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Biochim Biophys Acta. 2009 Jun;1791(6):501-6. doi: 10.1016/j.bbalip.2008.10.010. Epub 2008 Nov 7.

Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis.

Author information

1
Department of Nutrition, CB# 7461, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA. This step initiates the synthesis of all the glycerolipids and evidence from gain-of-function and loss-of-function studies in mice and in cell culture strongly suggests that each isoform contributes to the synthesis of triacylglycerol. Much work remains to fully delineate the regulation of each GPAT isoform and its individual role in triacylglycerol synthesis.

PMID:
19038363
PMCID:
PMC2737689
DOI:
10.1016/j.bbalip.2008.10.010
[Indexed for MEDLINE]
Free PMC Article

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