Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2008 Nov 26;60(4):570-81. doi: 10.1016/j.neuron.2008.08.022.

The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions.

Author information

1
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

Chronic complex regional pain syndrome (CRPS) is a debilitating pain condition accompanied by autonomic abnormalities. We investigated gray matter morphometry and white matter anisotropy in CRPS patients and matched controls. Patients exhibited a disrupted relationship between white matter anisotropy and whole-brain gray matter volume; gray matter atrophy in a single cluster encompassing right insula, right ventromedial prefrontal cortex (VMPFC), and right nucleus accumbens; and a decrease in fractional anisotropy in the left cingulum-callosal bundle. Reorganization of white matter connectivity in these regions was characterized by branching pattern alterations, as well as increased (VMPFC to insula) and decreased (VMPFC to basal ganglion) connectivity. While regional atrophy differentially related to pain intensity and duration, the strength of connectivity between specific atrophied regions related to anxiety. These abnormalities encompass emotional, autonomic, and pain perception regions, implying that they likely play a critical role in the global clinical picture of CRPS.

PMID:
19038215
PMCID:
PMC2637446
DOI:
10.1016/j.neuron.2008.08.022
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center